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Sulindac

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Formula: C20H17FO3S
CAS: 38194-50-2
search Element: sulindac

Identification

Structural Formula
Sulindac
CAS:
38194-50-2
EINECS:
253-819-2
Molecular Formula:
C20H17FO3S
MDL:
MFCD00599589
SMILES:
CC1=C(C2=C(/C1=C/C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
Synonym:
sulreuma ; sulinol ; clisundac ; saldac ; reumyl ; clinoril ; mobilin ; (z)-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid ; mk 231 ; aclin ; 1h-indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1z)- ; mk-231 ; sudac ; imbaral ; artribid ; arthrocine ; 1h-indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (z)- ; aflodac ; reumofil


Description

Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. Sulindac metabolizes to sulindac sulfide, a Cox (cyclooxygenase) inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.


Suppliers

Aozeal Certified Standards (AOCS), Inc.
S0103.00
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI5522208
H&Z Industry Co.,Ltd
HIC160640
Shandong SanYoung Industry Co., Ltd
SSI2801120
Chemlyte Solutions
CS144432
Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT4082040
CSNpharm, Inc.
CSN12016
Hangzhou Keying Chem Co., Ltd.
HKC240960
Sigma-Aldrich International GmbH
SI256768
Finetech Industry Limited
FIL200800
CM Fine Chemicals
CFC136544
AK Scientific, Inc.
AS152456
Xingrui Industry Co., Limited
XIL232928
Leap Chem Co., Ltd
LC144432
Santa Cruz Biotechnology, Inc.
202823
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CAS equal suppliers

(1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Gihi Chemicals Co., Limited
GCL30186120744
(1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
BLD Pharmatech Ltd
BP2012460372

Prices & Availability




Data is processed


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Properties for Sulindac

Molecular Weight:
356.42 g·mol−1
Density:
1.38 g/cm3
Melting point:
182-185 °C
Boiling point:
581.6 °C at 760 mmHg
Flash point:
305.6 °C
Solubility:
Soluble in water (0.05 mg/ml at 25° C), methanol (50 mg/ml), ethanol (9 mg/ml at 25° C), DMSO (71 mg/ml at 25° C), and DMF (~ 30 mg/ml).
Physical Description:
yellow crystalline solid
Transport Information:
UN 3249
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Hazard Statements

GHS06

GHS06
Toxic
  • Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R42/43 - May cause sensitization by inhalation and skin contact
R63 - Possible risk of harm to the unborn child
Hazard Classes:
6.1(b)
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
Store at RT
RID/ADR certification :
3249
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Alternative Distributors of [Sulindac]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | BOC Sciences | Inter-Chemical Ltd. | Jinan Great Chemical Co., Ltd. | TCS INDUSTRY LTD. | Lanospharma Laboratories Co., Ltd. | Xiang Ding Chemical International Co., Ltd | New Dragon Industrial Co., Ltd | Watson International Ltd | Hallochem Pharma Co., Ltd. | Yongyi Chemicals Group Co., Ltd. | Shanghai Eagle Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | Green Fine Chemical (Shanghai) Co., Ltd. | Clearsynth Canada INC. | Ningbo Medicn Pharmaceutical Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Nantong Qihai Chemicals Co., Ltd. | Shanghai AOKChem Group Limited | Taizhou Xingming Pharmaceutical Co.,Ltd | Suzhou Vosun Chemical Co.,Ltd. | Haihang Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Bichem Lab Co., Ltd. | Suzhou Sibian Chemical Technology Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd.

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