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Oxaliplatin

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Formula: C8H14N2O4Pt
CAS: 61825-94-3
search Element: oxaliplatin
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Identification

Structural Formula
Oxaliplatin
CAS:
61825-94-3
EINECS:
Molecular Formula:
C8H14N2O4Pt
MDL:
MFCD00866327
SMILES:
C1CC[C@H]([C@@H](C1)N)N.C(=O)(C(=O)[O-])[O-].[Pt+4]
Synonym:
p-54780 ; elocatin ; elplat ; nsc-266046 ; lipoxal ; 1-ohp ; ι-ohp ; eloxatin ; dacplat ; rp-54780


Description

Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin, the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin or Carboplatin, and shows antitumor activity in cell lines with acquired Cisplatin resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently.


Suppliers

Shandong SanYoung Industry Co., Ltd
SSI3851540
+
Ambeed, Inc.
A100048
+
H&Z Industry Co.,Ltd
HIC220880
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI7593036
+
Shandong Minglang Chemical Co., Ltd
SMC3851540
+
Guangzhou Topwork Chemical Co., Ltd.
GTC3961584
+
Heraeus Deutschland GmbH & Co. KG
HDC3631452
Alfa (A Johnson Matthey Company)
A3521056
BoomKing Industrial Co.,Limited
BIC3411364
+
Xiamen Equation Chemical Co.,Ltd
XECC3521760
+
Shanghai UCHEM Inc.
UCHEM-4927
Hainan Zhongxin Chemical Co., Ltd.
HZC3741496
+
Aecochem Corp.
AC154462
+
CSNpharm, Inc.
CSN11626
Wanko Chemical Co., Ltd.
WC264792
Sigma-Aldrich International GmbH
SI3521056
+
scienTEST - bioKEMIX GmbH
S-B2751100
+
Finetech Industry Limited
FIL2751100
+
Carbone Scientific Co., Ltd.
CS308924
+
Hefei Hirisun Pharmatech Co., Ltd
HR130399
+
CM Fine Chemicals
CFC187748
AK Scientific, Inc.
AS209627
+
Xingrui Industry Co., Limited
XIL3191276
+
BOC Sciences
BS132396
+
Amadis Chemical Company Limited
ACCL3411705
+
Leap Chem Co., Ltd
LC198594
+
Santa Cruz Biotechnology, Inc.
202270
Dayang Chem (Hangzhou) Co.,Ltd.
DC3411364
+
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Umicore AG & Co. KG | Precious Metals Chemistry
3000036133
(1R,2R)-Cyclohexane-1,2-diamine; 1,3-dioxa-2$l^-platinacyclopentane-4,5-dione
Manchester Organics Limited
Y32981

Prices & Availability




Data is processed


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Properties for Oxaliplatin

Molecular Weight:
397.29 g·mol−1
Melting point:
>245° C (dec.)
Solubility:
Soluble in water (7.9 mg/ml), methanol (slightly), and DMSO (50 mM). Insoluble in ethanol.
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
R40 - Limited evidence of a carcinogenic effect
R42/43 - May cause sensitization by inhalation and skin contact
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Classes:
6.1(a)
Hazard Symbols:
Xn, Xi
Hazard symbol Xn Hazard symbol Xi
Storage temperature :
Store at +4 °C
RID/ADR certification :
2811
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Alternative Distributors of [Oxaliplatin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Inter-Chemical Ltd. | World Biopharma Group Limited / World (Jiangsu) Industry Co.,Ltd | Rongkang Industry Co.,Ltd - (NSTU Chemicals Hanggzhou Co.,) | Molekula GmbH | CCS. CHEM. Co., Ltd. | Hallochem Pharma Co., Ltd. | Shanghai Eagle Chemical Co., Ltd. | 3B Scientific Corporation | Jiangsu Guotai International Group Co., Ltd. | Kinfon Pharmaceutical and Chemical Service Co., Ltd. | Hangzhou Sida Organic Chemical Co., Ltd. | Xiang Ding Chemical International Co., Ltd | CNCCC Sichuan Co., Ltd. | Vesino Industrial Co., Ltd. | Pharmasi Chemicals Co., Ltd. | Duheng Bio-tech Co., Ltd. | Changzhou An-Yuan Imp. & Exp. Corporation | Zouping Mingxing Chemical Co., Ltd. | Unispec Chemicals Co. | New Dragon Industrial Co., Ltd | Zhejiang Esun Chemical Co., Ltd. | Discovery Fine Chemicals Limited | Hangzhou Hysen Pharma Co., Ltd. | Jinan Wedo Industrial Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | SYNCHEM OHG | Shanghai Richem International Co., Ltd. | Shanghai Chemsors chemicals Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Ark Pharm, Inc. | Hangzhou Pharma & Chem Co. Ltd. | Junwee Chemical Co., Ltd. | Nantong Wanrong International Trading Co., Ltd. | Keen Union International Limited | Jinan Great Chemical Co., Ltd. | Tai Hua Industries Co., Limited | Acopin Industrial Limited | East Chemical Industry Co., Ltd. | Ruiyuan Group Limited | Shanghai Witofly Chemical Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Chempion International Co Ltd | Watson International Ltd | Pharmfar Co., Ltd. | Aopharm | BOC Sciences | Sunbow Biotech Ltd. | Finetech Industry Limited | Jinan Haohua Industry Co., Ltd. | Beijing Mediking Biopharm Co., Ltd. | Trademax Phamaceuticals & Chemicals Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Green Fine Chemical (Shanghai) Co., Ltd. | scienTEST | Clearsynth Canada INC. | Haihang Industry Co., Ltd.

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