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Necrostatin-1

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Formula: C13H13N3OS
CAS: 4311-88-0
search Element: necrostatin
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Identification

Structural Formula
Necrostatin-1
CAS:
4311-88-0
EINECS:
Molecular Formula:
C13H13N3OS
MDL:
MFCD00056916
SMILES:
CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
Synonym:
nec 1 ; necrostatin-1 ; mth-dl-tryptophan ; iflab-bb f0911-6127 ; necrostatin-1, >=98% ; 5-(indol-3-ylmethyl)-3-methyl-2-thio-hydantoin ; mth-dl-tryptophan methylthiohydantoin-dl-tryptophan ; methylthiohydantoin-dl-tryptophan, mth-dl-tryptophan ; 5-(1h-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone ; 5-(1h-indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone


Description

Necrostatin-1 is a potent and selective inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.


Suppliers

Aea.ltd
A91182
+
Alfa (A Johnson Matthey Company)
A4161248
Bachem AG
Q-2720.0010
BOC Sciences
BS156468
+
Amadis Chemical Company Limited
ACCL4032015
+
Leap Chem Co., Ltd
LC234702
+
Santa Cruz Biotechnology, Inc.
200142
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CAS equal suppliers

Necrostatin 1
Ambeed, Inc.
A181851
Necrostatin 1
CSNpharm, Inc.
CSN11637
MTH-DL-Tryptophan
Hangzhou J&H Chemical Co., Ltd.
HJC5272108
5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE
Chemieliva Pharmaceutical Co., Ltd.
CP1445543365
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Finetech Industry Limited
FIL1032541300
4-Imidazolidinone, 5-(1h-indol-3-ylmethyl)-3-methyl-2-thioxo-
Angene International Limited
AGN-PC-0JVPC4

Prices & Availability




Data is processed


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Properties for Necrostatin-1

Molecular Weight:
259.33 g·mol−1
Density:
1.40±0.1 g/cm3 (20 °C 760 Torr)
Melting point:
151 °C
Boiling point:
441.92 °C at 760 mmHg
Solubility:
DMSO: >10 mg/mL
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [Necrostatin-1]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

D&P Global Chemical Co., Ltd

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MSDS:
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