Mitomycin C | CAS 50-07-7 | Chemical-Suppliers

Element: mitomycin

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C-S » Chemicals » mitomycin-PX69997

Identification

Mitomycin C

CAS:

50-07-7

EINECS:

200-008-6

Molecular Formula:

C₁₅H₁₈N₄O₅

MDL:

MFCD00078109

SMILES:

CO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O

Synonym:

ametycine ; mitomyci ; mitonco ; nsc26980 ; mitocin c ; mmc ; mytomycin ; mitoplus ; nsc-26980 ; ametycin

Description

Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent, making it a useful antibiotic and antitumor compound. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.

Suppliers

Shandong Ench Chemical Co.,Ltd

SECC6603300

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI15186072

Indofine Chemical Co, Inc.

Bio-268

Alfa (A Johnson Matthey Company)

A7042112

Jinan Honestpharm Co., Ltd

JH5721716

Xiamen Equation Chemical Co.,Ltd

XECC7043520

Aecochem Corp.

AC308924

Hangzhou Keying Chem Co., Ltd.

HKC6602640

Hangzhou Lingrui Chemical Co., Ltd.

HLC7703080

scienTEST - bioKEMIX GmbH

S-B5502200

Iris Biotech GmbH

LS-1041

AK Scientific, Inc.

AS4181254

Xingrui Industry Co., Limited

XIL6382552

BOC Sciences

BS264792

Leap Chem Co., Ltd

LC3961188

Santa Cruz Biotechnology, Inc.

3514

Chemos GmbH & Co. KG

CC4401320

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TCI Chemicals (India) Pvt. Ltd.

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HZC3061224

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X´ian Taicheng Chem Co., Ltd

XTC2611044

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Hangzhou J&H Chemical Co., Ltd.

HJC2791116

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Sigma-Aldrich International GmbH

SI288864

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Carbone Scientific Co., Ltd.

CS252756

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LGM Pharma

LP90270

Mitomycin

Pharmaffiliates Analytics & Synthetics Pvt. Limited

PA 40 04000

Mitomycin

Gihi Chemicals Co., Limited

GCL243972

Mitomycin C w/NaCl

United States Biological

M4000-01

Mitomycin C (4% in NaCl)

Santa Cruz Biotechnology, Inc.

sc-286964

Mitomycin C Pure (NaCl-Free)

United States Biological

M4000

Mitomycin C, Mutamycin, Ametycin, Mitocin-C

Salsbury Chemicals, Inc.

SC516015480

Prices & Availability

Data is processed

Properties for Mitomycin C

Molecular Weight:

334.33 g·mol−1

Density:

1.56 g/cm³ (Predicted)

Melting point:

360 °C

Boiling point:

581.78° C at 760 mmHg (Predicted)

Solubility:

H₂O: 4 mL/vial Stock solutions should be filter sterilized and stored at 2-8 °C in the dark., clear to slightly hazy, blue to purple

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R25 - Toxic if swallowed
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed
R40 - Limited evidence of a carcinogenic effect
R45 - May cause cancer

Safety Codes:

S22 - Do not breathe dust
S28 - After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use

Hazard Classes:

6.1(a)

Hazard Symbols:

T, Xn, T+

Storage temperature :

2-8°C

RID/ADR certification :

UN 3462 6.1 / PG 2

Alternative Distributors of [Mitomycin C]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified