Chemical-Suppliers Chemical-Suppliers

Fasudil, Monohydrochloride Salt

×
Formula: C14H17N3O2S.HCl
CAS: 105628-07-7

Identification

Structural Formula
Fasudil, Monohydrochloride Salt
CAS:
105628-07-7
EINECS:
Molecular Formula:
C14H17N3O2S.HCl
MDL:
MFCD00943198
SMILES:
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
Synonym:
fasudil hcl ; ha-1077 dihydrochloride ; fasudil hydrochloride ; fasudil hcl, >=99% ; fasudel ; ha-1077 ; hydrochloride fasudil ; fasudil hcl (ha-1077) ; fasudil (ha-1077) ; fasudil (ha-1077) hcl


Description

Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.


Suppliers

Santa Cruz Biotechnology, Inc.
203418
Get Quick Quote

CAS equal suppliers

Fasudil HCl
Aozeal Certified Standards (AOCS), Inc.
F0060.03
Fasudil HCl
CSNpharm, Inc.
CSN10984
Fasudilhydrochloride
Huateng Pharmaceutical Co.,Ltd
80071744
Fasudil Hydrochloride
TCI Chemicals (India) Pvt. Ltd.
F0839
Fasudil hydrochloride
AK Scientific, Inc.
AS7982394
Fasudil hydrochloride
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC20941
Fasudil hydrochloride
Dayang Chem (Hangzhou) Co.,Ltd.
DC13025208
Fasudil hydrochloride
Hangzhou Trylead Chemical Technology Co., Ltd.
HTCT19329660
Fasudil hydrochloride
Simagchem Corporation
SC8822646
Fasudil hydrochloride
Chemieliva Pharmaceutical Co., Ltd.
CP14704410
Fasudil hydrochloride
Aecochem Corp.
AC5881764
Fasudil hydrochloride
Leap Chem Co., Ltd
LC7562268
Fasudil hydrochloride
Hangzhou J&H Chemical Co., Ltd.
HJC13025208
Fasudil hydrochloride
Zhejiang Hongxin Chemical
ZHC10504200
Fasudil hydrochloride
Capot Chemical Co., Ltd.
21890
Fasudil hydrochloride
Hefei Hirisun Pharmatech Co., Ltd
HR010361
Fasudil hydrochloride
Amadis Chemical Company Limited
ACCL13026510
Fasudil hydrochloride
Skyrun Industrial Co., Ltd.
SI11343402
Fasudil hydrochloride
Purestar Chem Enterprise Co., Ltd.
PCE14285712
Fasudil hydrochloride
Haihang Industry Co., Ltd.
HI10923276
Fasudil hydrochloride
Pharmacore Co., Limited
PL9662898
Fasudil hydrochloride
Hangzhou Lingrui Chemical Co., Ltd.
HLC14705880
Fasudil hydrochloride
Wanko Chemical Co., Ltd.
WC10083024
Fasudil hydrochloride
BOC Sciences
BS5041512
Fasudil hydrochloride
Hangzhou Yuhao Chemical Technology Co., Ltd
YH23122
Fasudil Hydrochloride
Ambeed, Inc.
A193859
Fasudil hydrochloride
Excenen Pharmatech Co., Ltd.
EX-A060
Fasudil hydrochloride
Ascender Chemical Co.,Ltd
ACC10504200
Fasudil hydrochloride
Jiwan Pharmaceutical Technology Co., Ltd.
JPT17226888
Fasudil hydrochloride
Sancai Industry Co.,Ltd.
SIC10084032
Fasudil hydrochloride
FUDI Chemical Co. Ltd.
FCC9243696
Fasudil hydrochloride
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI289811592
Fasudil hydrochloride
Xingrui Industry Co., Limited
XIL12184872
Fasudil hydrochloride
Shandong Minglang Chemical Co., Ltd
SMC14705880
Fasudil hydrochloride
Gihi Chemicals Co., Limited
GCL11344536
Fasudil hydrochloride
Changzhou Union Chemicals Co.,Ltd.
CUCC14287140
Fasudil hydrochloride
Hangzhou Keying Chem Co., Ltd.
HKC12605040
Fasudil hydrochloride
Xiamen Equation Chemical Co.,Ltd
XECC13446720
Fasudil hydrochloride
Aea.ltd
A294588
Fasudil hydrochloride
Shandong SanYoung Industry Co., Ltd
SSI14705880
Fasudil hydrochloride
Chemlyte Solutions
CS7562268
Fasudil monohydrochloride, 99+%
Alfa (A Johnson Matthey Company)
A19845952
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride
BLD Pharmatech Ltd
BP615618468

Prices & Availability




Data is processed


x

Properties for Fasudil, Monohydrochloride Salt

Molecular Weight:
327.83 g·mol−1
Melting point:
208-215° C
Boiling point:
506.2° C at 760 mmHg (Predicted)
Solubility:
H2O: >200 mg/mL
x

Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

x

Alternative Distributors of [Fasudil, Monohydrochloride Salt]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH

x

Downloads

Mol File:
-/-
MSDS:
-/-