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Cycloheximide

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Formula: C15H23NO4
CAS: 66-81-9
search Element: cycloheximide

Identification

Structural Formula
Cycloheximide
CAS:
66-81-9
EINECS:
200-636-0
Molecular Formula:
C15H23NO4
MDL:
MFCD00082346
SMILES:
C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
Synonym:
hizarocin ; naramycin ; kaken ; actidionebr ; ft 3422-2 ; actidionepm ; 980u/mg ; actispray ; aktidion ; actidione


Description

Cycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria. It has been reported to inhibit the synthesis of both proteins and macromolecules, as well as affect apoptosis in eukaryotes. Inhibition of protein synthesis is believed to be mediated through DNA translation arrest, as demonstrated in rat thymocytes. Although cycloheximide has been reported to induce apoptosis in various cells, it has also been shown to inhibit or delay induced apoptosis. These observations suggest that cycloheximide's effect on apoptosis may not be solely through protein translation arrest and that other mechanisms may be involved. Cycloheximide has also been reported to inhibit FKBP12 (peptidylprolylisomerase hFKBP12, PPIase hFKBP12) via competitive inhibition.


Suppliers

Chemlyte Solutions
CS234702
Serva Electrophoresis GmbH
SE3381014
Hangzhou Keying Chem Co., Ltd.
HKC3901560
Sigma-Aldrich International GmbH
SI4161248
scienTEST - bioKEMIX GmbH
S-B3251300
Carbone Scientific Co., Ltd.
CS3641092
CM Fine Chemicals
CFC221884
Santa Cruz Biotechnology, Inc.
3508
Dayang Chem (Hangzhou) Co.,Ltd.
DC4031612
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CAS equal suppliers

Actidione
Chemieliva Pharmaceutical Co., Ltd.
CP315945
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Leap Chem Co., Ltd
LC162486
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Hangzhou J&H Chemical Co., Ltd.
HJC2791116
Actidione
Haihang Industry Co., Ltd.
HI234702
Actidione
Autech Industry Co.,Limited
AIC243972
Actidione
Gihi Chemicals Co., Limited
GCL243972
Actidione
Krada CPS Industry S.L
KCIS198990
Cycloheximide, 95%
Acros Organics BVBA
AOB3421368
Cycloheximide Solution 50mg/ml
United States Biological
C8500-10
3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide
Indofine Chemical Co, Inc.
Bio-160
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxo-cyclohexyl]-2-hydroxy-ethyl]piperidine-2,6-dione
Manchester Organics Limited
P50292

Prices & Availability




Data is processed


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Properties for Cycloheximide

Molecular Weight:
281.34742 g·mol−1
Density:
1.1 g/cm3 (Predicted)
Melting point:
111-116 °C
Boiling point:
491.8 °C at 760 mmHg (Predicted)
Solubility:
Soluble in water (20 mg/ml at 2° C), ethanol (50 mM), chloroform, and ether. Insoluble in saturated hydrocarbons. (Do not store aqueous solutions for more than one day)
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R28 - Very toxic if swallowed
R38 - Irritating to skin
R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R61 - May cause harm to the unborn child
R68 - Possible risk of irreversible effects
Safety Codes:
S28 - After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
Hazard Classes:
6.1(a)
Hazard Symbols:
Xn, T, N, T+
Hazard symbol T Hazard symbol N Hazard symbol Xn Hazard symbol T+
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 1
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Alternative Distributors of [Cycloheximide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Advance Scientific & Chemical, Inc. | Biosynth AG | Molekula GmbH | Discovery Fine Chemicals Limited | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Ubichem PLC | Suzhou Rovathin Pharmatech Co., Ltd | Atomole Scientific Co., Ltd. | Wuxi Mizat Chemical Technology Co., Ltd. | Carl Roth GmbH + Co KG | East Chemical Industry Co., Ltd. | Cfm Oskar Tropitzsch GmbH | BOC Sciences | Suzhou Bichal Biological Technology Co., Ltd. | Pfaltz & Bauer, Inc. | scienTEST | Gihi Chemicals Co., Limited

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