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Cisplatin

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Formula: Cl2(NH3)2Pt
CAS: 15663-27-1
search Element: cisplatin
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Identification

Structural Formula
Cisplatin
CAS:
15663-27-1
EINECS:
239-733-8
Molecular Formula:
Cl2(NH3)2Pt
MDL:
MFCD00011623
SMILES:
N.N.Cl[Pt+2]Cl
Synonym:
tr170 ; platinex ; cpdd ; randa ; cacp ; cpdc ; nk801 ; cddp ; cis-ddp ; platinol


Description

Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin. Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


Suppliers

Nantong Xindao Biotech Ltd
NXB234936
+
Ambeed, Inc.
A210558
+
H&Z Industry Co.,Ltd
HIC180720
+
Guangzhou Topwork Chemical Co., Ltd.
GTC3241296
+
Xiamen Equation Chemical Co.,Ltd
XECC2881440
+
Hainan Zhongxin Chemical Co., Ltd.
HZC3061224
+
Aecochem Corp.
AC126378
+
CSNpharm, Inc.
CSN10657
Hangzhou Lingrui Chemical Co., Ltd.
HLC3151260
+
Sigma-Aldrich International GmbH
SI288864
+
Finetech Industry Limited
FIL225900
+
Hefei Hirisun Pharmatech Co., Ltd
HR130398
+
AK Scientific, Inc.
AS171513
+
Simagchem Corporation
SC189567
+
Xingrui Industry Co., Limited
XIL2611044
+
BOC Sciences
BS108324
+
Leap Chem Co., Ltd
LC162486
+
Santa Cruz Biotechnology, Inc.
200896
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Prices & Availability




Data is processed


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Properties for Cisplatin

Molecular Weight:
300.05 g·mol−1
Density:
3,7 g/cm3
Melting point:
340 °C (dec.)(lit.)
Solubility:
Soluble in DMSO (25 mg/ml), water (0.25 g/100ml) at 25° C, ethanol (<1 mg/ml) at 25° C, and DMF (16 mg/ml).
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Hazard Statements

GHS06

GHS06
Toxic
  • Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R41 - Risk of serious damage to eyes
R42/43 - May cause sensitization by inhalation and skin contact
R45 - May cause cancer
R46 - May cause inheritable genetic damage
R60 - May impair fertility
Safety Codes:
S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S39 - Wear eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Symbols:
T
Hazard symbol T
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Alternative Distributors of [Cisplatin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Rongkang Industry Co.,Ltd - (NSTU Chemicals Hanggzhou Co.,) | Hallochem Pharma Co., Ltd. | Shanghai Eagle Chemical Co., Ltd. | Jiangsu Guotai International Group Co., Ltd. | Shanghai Chemicals & Pharmaceuticals Co., Limited | Qichun QiLong Chemical Co., Ltd. | Nantong Wanrong International Trading Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | Vesino Industrial Co., Ltd. | Pharmasi Chemicals Co., Ltd. | Ningbo Pangs Chem Int'l Co., Ltd. | Shanghai Henghe Pharma-Tech Co., Ltd. | Unispec Chemicals Co. | Abtonsmart Chemicals Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Hangzhou Hysen Pharma Co., Ltd. | Jinan Wedo Industrial Co., Ltd. | Shanghai AOKChem Group Limited | Shanghai Richem International Co., Ltd. | Share Chemical Co., Ltd. | TRUST&WE Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Hangzhou Pharma & Chem Co. Ltd. | Lanospharma Laboratories Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | Junwee Chemical Co., Ltd. | Jinan Great Chemical Co., Ltd. | Acopin Industrial Limited | Hangzhou Imaginechem Co., Ltd. | Ruiyuan Group Limited | Benro Internatinal Co., Linc | API Vanguard | Discovery Fine Chemicals Limited | Watson International Ltd | Aopharm | BOC Sciences | Jinan Haohua Industry Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Trademax Phamaceuticals & Chemicals Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Wanko Chemical Co., Ltd.

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