Bosutinib | CAS 380843-75-4 | Chemical-Suppliers

Element: bosutinib

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C-S » Chemicals » bosutinib-PX80145

Identification

Bosutinib

CAS:

380843-75-4

EINECS:

Molecular Formula:

C₂₆H₂₉Cl₂N₅O₃

MDL:

MFCD07367846

SMILES:

CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC

Synonym:

bosulif(bosutinib) ; way-173606 ; bosutinib for research ; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile ; 3-quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]- ; bosutinib ( ski-606 ) ; ski-606 ; bosutinib(tinibs ) ; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile bosutinib (ski-606) ; bosutinib

Description

Bosutinib (SKI-606) is a potent c-Abl, Bcr-Abl, and Src-Abl kinase inhibitor, shown to effectively interfere with the progress of chronic myelogenous leukemia (CML). In a competitive study with Imatinib, Bosutinib was shown to inhibit Bcr-Abl kinase activity in CD34⁺ CML cells more potently than Imatinib. Activity of Src-Abl has been implicated in the development of other non-CML malignancies, and Bosutinib has demonstrated in studies to suppress breast cancer growth and migration.

Suppliers

ZHIWE ChemTech Co Ltd

ZC189567

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

Aea.ltd

A63126

Hangzhou Cherry Pharmaceutical Technology Co., Ltd.

HCPT4592295

BoomKing Industrial Co.,Limited

BIC2791116

Xiamen Equation Chemical Co.,Ltd

XECC2881440

Aecochem Corp.

AC126378

CSNpharm, Inc.

CSN11935

Hangzhou Lingrui Chemical Co., Ltd.

HLC3151260

Finetech Industry Limited

FIL225900

Carbone Scientific Co., Ltd.

CS252756

Pharmacore Co., Limited

PL207621

Hefei Hirisun Pharmatech Co., Ltd

HR012752

CM Fine Chemicals

CFC153612

AK Scientific, Inc.

AS171513

Simagchem Corporation

SC189567

Capot Chemical Co., Ltd.

22404

BOC Sciences

BS108324

Amadis Chemical Company Limited

ACCL2791395

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

202084

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CAS equal suppliers

SKI606

Excenen Pharmatech Co., Ltd.

EX-A391

SKI-606

Aea.ltd

A4998

4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

BLD Pharmatech Ltd

BP2268068040

Prices & Availability

Data is processed

Properties for Bosutinib

Molecular Weight:

530.45 g·mol−1

Density:

1.36

Melting point:

116-120 °C

Boiling point:

649.72° C at 760 mmHg (Predicted)

Solubility:

Soluble in methanol, DMSO (≥15 mg/ml), and ethanol (25 mM). Very poorly soluble in water. Maximum solubility in plain water is estimated to be about 10-50 µM. Buffers, serum, or other additives may increase or decrease the aqueous solubility.

Safety & Transport Information

Risk Codes:

R36 - Irritating to eyes

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

Hazard Symbols:

Storage temperature :

room temp

Alternative Distributors of [Bosutinib]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified